RESEARCH UNIT - GRUPPO DI RICERCA
Domenicantonio Rotiroti
WEB ADDRESS / INDIRIZZO INTERNET

 
TEAM LEADER / RESPONSABILE

Domenicantonio Rotiroti rotiroti@unicz.it 
RESEARCH GROUP MEMBERS / COMPONENTI DEL GRUPPO DI RICERCA

1 Maria Tiziana Corasaniti mtcorasa@unicz.it 
2 Michele Navarra navarra@unicz.it 
3 Rossella Russo    
AFFILIATION / AFFILIAZIONE

Dipartimento di Scienze Farmacobiologiche   WEB
Facoltà di Farmacia   WEB
Università degli Studi “Magna Graecia”di Catanzaro   WEB
ADDRESS / INDIRIZZO

c/o Complesso “Ninì Barbieri” 88021 Roccelletta di Borgia (Catanzaro)
TELEPHONE / TELEFONO

+39-0961-391157
FAX

+39-0961-391490
RESEARCH TOPICS / LINEE DI RICERCA

1 Study of the mechanisms underlying neuronal damage in in vivo and in vitro experimental models of excytotoxicity and neuroinflammation and characterization of novel neuroprotective approaches
17 Study of the pharmacological profile of natural products
COLLABORATIONS / COLLABORAZIONI

Prof. G. Bagetta; Department of Pharmacobiology, University of Calabria, Cosenza (Italy)  
Prof. M. Maccarrone; Department of Biomedical Sciences, University of Teramo, Teramo (Italy)  
Prof. A. Finazzi-Agrò; Department of Experimental Medicine and Biomedical Sciences, University of Rome “Tor Vergata”, Rome (Italy)  
Prof. A. Garcia; Institut de Biotecnologia y Biomedicina “Vincent Villar i Palisi- Universitat Autonoma de Barcelona (Spain)  
GRANTS / FINANZIAMENTI

AIDS Project-ISS Rome (2001-2004)
Calabria Region-Department of Agriculture, 2003
University”Magna Graecia” of Catanzaro, COFIN 2004
ADDITIONAL INFORMATION / INFORMAZIONI AGGIUNTIVE

 
PUBLICATIONS 2001-2004 / PUBBLICAZIONI 2001-2004

1 Corasaniti MT, Turano P, Bilotta A, Malorni W, Stringaro AR, Nisticò R, Finazzi-Agrò A and Bagetta G (2001) Evidence that increases of mitochondrial immunoreactive IL-1beta by HIV-1 gp120 implicate in situ cleavage of pro-IL-1beta in the neocortex of rat. J. Neurochem. 78: 611-618, 2001.
2 Corasaniti MT, Bilotta A, Strongoli MC, Navarra M, Bagetta G and Di Renzo G (2001) HIV-1 coat protein gp120 stimulates interleukin-1beta secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death. Br. J. Pharmacol., 134: 1344-1350.
3 Navarra M, Romano C, Lorenzon T, Rotiroti D & Di Renzo G (2001) Ethanol exposure inhibits the cytotoxic effect induced by gp120 in neuroblastoma cells. J. Neurosci. Res. 65: 354-361.
4 Bagetta G, Paoletti AM, Leta A, Del Duca C, Nisticò R, Rotiroti D & Corasaniti MT (2002). Abnormal expression of neuronal nitric oxide synthase (nNOS) triggers limbic seizures and hippocampal damage in rat. Biochem. Biophys. Res. Commun. 291: 255-260.
5 Maccarrone M, Navarra M, Catani V, Corasaniti MT, Bagetta G & Finazzi-Agrò A (2002) Cholesterol-dependent modulation of the toxicity of HIV-1 coat protein gp120 in human neuroblastoma cells. J. Neurochem. : 1444-1452.
6 Russo R, Navarra M., Rotiroti D & Di Renzo G (2003). Evidence for a role of protein tyrosine kinases in cell death induced by gp120 in CHP100 neuroblastoma cells. Toxicol. Lett. 139: 207-11.
7 Catani MV, Corasaniti MT, Ranalli M, Amantea D, Litovchick A, Lapidot A, Melino G (2003) The Tat antagonist neomycin B hexa-arginine conjugate inhibits gp120-induced death of human neuroblastoma cells. J. Neurochem. 84: 1237-1245.
8 Maccarrone M, Piccirilli S, Battista N, Del Duca C, Nappi G, Corasaniti MT, Finazzi-Agro A, Bagetta G (2004) Enhanced anandamide degradation is associated with neuronal apoptosis induced by the HIV-1 coat glycoprotein gp120 in the rat neocortex. J. Neurochem. 89: 1293-300.
9 Bagetta G, Chiappetta O, Amantea D, Iannone M, Rotiroti D, Costa A, Nappi G, Corasaniti MT (2004) Estradiol reduces cytochrome c translocation and minimizes hippocampal damage caused by transient global ischemia in rat. Neurosci. Lett. 16: 87-91.
10 Navarra M, Pedraza CE, Sardon T, Baltrons MA & Garcia A (2004). HIV-1 coat protein gp120 decreases NO-dependent cyclic GMP accumulation in rat brain astroglia by increasing cyclic GMP phosphodiesterase activity. Neurochem. Int. : 937-46.
LAST UPDATE / ULTIMO AGGIORNAMENTO DATI

January 14, 2004